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專業詞匯

Abbreviation

Description

Abl

V-abl Abelson murine leukemia viral oncogene homolog 1

ALK

anaplastic lymphoma kinase

ATM

Ataxia telangiectasia mutated

B-Raf

B-Raf proto-oncogene serine/threonine-protein kinase (B-RAF), also known   as V-raf murine sarcoma viral oncogene homolog B1

Bcl-2

B-cell lymphoma 2

bcr

breakpoint cluster region

Caspase

cysteine-aspartic proteases or cysteine-dependent aspartate-directed   proteases

CCR5

co-receptors chemokine receptor 5

CDK

Cyclin-dependent kinase

CFTR potentiator

Cystic fibrosis transmembrane conductance regulator

CTSK

Cathepsin K, abbreviated CTSK

c-Kit

CD117, also called KIT or C-kit receptor

c-Met

mesenchymal-epithelial transition factor

DNA-PK

DNA-dependent protein kinase

DPP-4

Dipeptidyl peptidase-4

EGFR

Epidermal growth factor receptor

Factor Xa

also known by the eponym Stuart-Prower factor or as prothrombinase

FGFR

Fibroblast growth factor receptor

FLT-3

fms-like tyrosine kinase receptor-3

FTS

farnesyl thiosalicylic

GSK-3

Glycogen synthase kinase 3

HER2

Human Epidermal growth factor Receptor 2

Hedgehog

an intercellular signaling molecule called Hedgehog (Hh)

HDAC

Histone deacetylase

HIF

Hypoxia-inducible factor

HSP-70

heat-shock protein-70

HSP-90

heat-shock protein-90

IGF-1R

Insulin-like growth factor 1 receptor

JAK

Janus kinase

JNK

c-Jun N-terminal kinases

Ksp

Kinesin spindle protein

MAPK

Mitogen-activated Protein Kinase

MEK

MAPK/ERK kinase

mGlu2/3 receptors

metabotropic glutamate receptors

mTOR

Mammalian target of rapamycin

NF-kB

Nuclear factor κ B

p38 MAPK

p38 Mitogen-activated Protein Kinase

p53

protein 53 or tumor protein 53

PARP

Poly (ADP-ribose) polymerase

PDGFR

platelet-derived growth factor receptor

PDK-1

phosphoinositide-dependent kinase-1

Rho

ρ factor

PI3K

Phosphatidylinositol 3-kinases

PKC

protein kinase C

PLK

Polo-like kinase

Ras

renin-angiotensin system

RNA Polymerase I

RNAP or RNApol

S1PR1

sphingosine-1-phosphate receptor 1,also known as S1P1 or EDG1 (endothelial   differentiation gene 1)

sPLA2

Secreted phospholipases A2

Src

Rous sarcoma oncogene cellular homolog

Stat

Signal Transducers and Activator of Transcription

Survivin

also called baculoviral inhibitor of apoptosis repeat-containing 5 or   BIRC5

TGF-beta

Transforming growth factor

TNF-alpha

Tumor necrosis factors

VEGFR-PDGFR

Vascular Endothelial Growth Factor Receptor -platelet derived growth   factor receptor

Wee1

Small cell protein, a mitotic inhibitor kinase

Wnt

a combination of Wg (wingless) and Int

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